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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha : |
30/08/2022 |
Actualizado : |
30/08/2022 |
Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
Autor : |
CARRACELAS, B.; NAVAJAS, E.; VERA, B.; CIAPPESONI, G. |
Afiliación : |
EMERITA BEATRIZ CARRACELAS MARQUEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; BRENDA VERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Genome-wide association study of parasite resistance to gastrointestinal nematodes in Corriedale sheep. |
Fecha de publicación : |
2022 |
Fuente / Imprenta : |
Genes, 2022, vol. 13, issue 9, 1548. OPEN ACCESS. doi: https://doi.org/10.3390/genes13091548 |
ISSN : |
e-ISSN 2073-4425 |
DOI : |
10.3390/genes13091548 |
Idioma : |
Inglés |
Notas : |
Article history: Received 25 May 2022; Revised 19 August 2022; Accepted 23 August 2022; Published 27 August 2022.
Correspondence: gciappesoni@inia.org.uy -- Academic Editor: Qiuyue Liu.
License: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
This article belongs to the Collection Feature Papers in Animal Genetics and Genomics: https://www.mdpi.com/journal/genes/topical_collections/feature_paper_animal |
Contenido : |
ABSTRACT.- Selection of genetically resistant animals is one alternative to reduce the negative impact of gastrointestinal nematodes (GIN) on sheep production. The aim of this study was to identify genomic regions associated with GIN resistance in Corriedale sheep by single-step genome-wide association studies (ssGWAS) using 170, 507 and 50K single nucleotide polymorphisms (SNPs). Analysis included 19,547 lambs with faecal egg counts (FEC) records, a pedigree file of 40,056 animals and 454, 711 and 383 genotypes from 170, 507 and 50K SNPs, respectively. Genomic estimated breeding values (GEBV) were obtained with single-step genomic BLUP methodology (ssGBLUP), using a univariate animal model, which included contemporary group, type of birth and age of dam as class fixed effects and age at FEC recording as covariate. The SNP effects as wells as p-values were estimated with POSTGSF90 program. Significance level was defined by a chromosome-wise False Discovery Rate of 5%. Significant genomic regions were identified in chromosomes 1, 3, 12 and 19 with the 170 SNP set, in chromosomes 7, 12 and 24 using the 507 SNP chip and only in chromosome 7 with the 50K SNP chip. Candidate genes located in these regions, using Oar_v4.0 as reference genome, were TIMP3, TLR5, LEPR and TLR9 (170 SNPs), SYNDIG1L and MGRN1 (507 SNP chip) and INO80, TLN2, TSHR and EIF2AK4 (50K SNP chip). These results validate genomic regions associated with FEC previously identified in Corriedale and other breeds and report new candidate regions for further investigation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. MenosABSTRACT.- Selection of genetically resistant animals is one alternative to reduce the negative impact of gastrointestinal nematodes (GIN) on sheep production. The aim of this study was to identify genomic regions associated with GIN resistance in Corriedale sheep by single-step genome-wide association studies (ssGWAS) using 170, 507 and 50K single nucleotide polymorphisms (SNPs). Analysis included 19,547 lambs with faecal egg counts (FEC) records, a pedigree file of 40,056 animals and 454, 711 and 383 genotypes from 170, 507 and 50K SNPs, respectively. Genomic estimated breeding values (GEBV) were obtained with single-step genomic BLUP methodology (ssGBLUP), using a univariate animal model, which included contemporary group, type of birth and age of dam as class fixed effects and age at FEC recording as covariate. The SNP effects as wells as p-values were estimated with POSTGSF90 program. Significance level was defined by a chromosome-wise False Discovery Rate of 5%. Significant genomic regions were identified in chromosomes 1, 3, 12 and 19 with the 170 SNP set, in chromosomes 7, 12 and 24 using the 507 SNP chip and only in chromosome 7 with the 50K SNP chip. Candidate genes located in these regions, using Oar_v4.0 as reference genome, were TIMP3, TLR5, LEPR and TLR9 (170 SNPs), SYNDIG1L and MGRN1 (507 SNP chip) and INO80, TLN2, TSHR and EIF2AK4 (50K SNP chip). These results validate genomic regions associated with FEC previously identified in Corriedale and other breeds an... Presentar Todo |
Palabras claves : |
FEC; Genomic regions; SsGWAS. |
Asunto categoría : |
L01 Ganadería |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16636/1/genes-13-01548-v2.pdf
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Marc : |
LEADER 02850naa a2200229 a 4500 001 1063548 005 2022-08-30 008 2022 bl uuuu u00u1 u #d 022 $ae-ISSN 2073-4425 024 7 $a10.3390/genes13091548$2DOI 100 1 $aCARRACELAS, B. 245 $aGenome-wide association study of parasite resistance to gastrointestinal nematodes in Corriedale sheep.$h[electronic resource] 260 $c2022 500 $aArticle history: Received 25 May 2022; Revised 19 August 2022; Accepted 23 August 2022; Published 27 August 2022. Correspondence: gciappesoni@inia.org.uy -- Academic Editor: Qiuyue Liu. License: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). This article belongs to the Collection Feature Papers in Animal Genetics and Genomics: https://www.mdpi.com/journal/genes/topical_collections/feature_paper_animal 520 $aABSTRACT.- Selection of genetically resistant animals is one alternative to reduce the negative impact of gastrointestinal nematodes (GIN) on sheep production. The aim of this study was to identify genomic regions associated with GIN resistance in Corriedale sheep by single-step genome-wide association studies (ssGWAS) using 170, 507 and 50K single nucleotide polymorphisms (SNPs). Analysis included 19,547 lambs with faecal egg counts (FEC) records, a pedigree file of 40,056 animals and 454, 711 and 383 genotypes from 170, 507 and 50K SNPs, respectively. Genomic estimated breeding values (GEBV) were obtained with single-step genomic BLUP methodology (ssGBLUP), using a univariate animal model, which included contemporary group, type of birth and age of dam as class fixed effects and age at FEC recording as covariate. The SNP effects as wells as p-values were estimated with POSTGSF90 program. Significance level was defined by a chromosome-wise False Discovery Rate of 5%. Significant genomic regions were identified in chromosomes 1, 3, 12 and 19 with the 170 SNP set, in chromosomes 7, 12 and 24 using the 507 SNP chip and only in chromosome 7 with the 50K SNP chip. Candidate genes located in these regions, using Oar_v4.0 as reference genome, were TIMP3, TLR5, LEPR and TLR9 (170 SNPs), SYNDIG1L and MGRN1 (507 SNP chip) and INO80, TLN2, TSHR and EIF2AK4 (50K SNP chip). These results validate genomic regions associated with FEC previously identified in Corriedale and other breeds and report new candidate regions for further investigation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. 653 $aFEC 653 $aGenomic regions 653 $aSsGWAS 700 1 $aNAVAJAS, E. 700 1 $aVERA, B. 700 1 $aCIAPPESONI, G. 773 $tGenes, 2022, vol. 13, issue 9, 1548. OPEN ACCESS. doi: https://doi.org/10.3390/genes13091548
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
Fecha actual : |
12/04/2023 |
Actualizado : |
12/04/2023 |
Tipo de producción científica : |
Artículos en Revistas Agropecuarias |
Autor : |
CIBILS-STEWART, X.; GONZALEZ, M.; PESSIO, M.; CALISTRO, P.; ROSSI, C.; GIAMBIASI, M.; CHIARAVALLE, W.; ABBATE, S.; BARAIBAR, N. |
Afiliación : |
XIMENA CIBILS-STEWART, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARY ALICIA GONZALEZ BOLLETTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MABEL ELIZABETH PESSIO TORRES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PABLO ANDRES CALISTRO PEREZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CARLOS ALBERTO ROSSI RODRIGUEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIO ALEJANDRO GIAMBIASI RODRIGUEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; WILLY CHIARAVALLE, Asesor privado; SILVANA ABBATE, CENUR Litoral Norte-EEMAC-Udelar; NICOLÁS BARAIBAR PEDERSEN, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
Título : |
Crónica del daño de la lagarta medidora (Rachiplusia nu) en soja Intacta®. |
Complemento del título : |
Cultivos. |
Fecha de publicación : |
2023 |
Fuente / Imprenta : |
Revista INIA Uruguay, Marzo 2023, no.72, p.53-58. |
Serie : |
(Revista INIA; 72). |
ISSN : |
1510-9011 |
Idioma : |
Español |
Contenido : |
En febrero de la pasada zafra se reportó, en nuestro país, la presencia y el daño de lagartas medidoras (Rachiplusia nu) en soja Bt (foto de portada y Figura 1).
Se presentan aquí los resultados del trabajo que procuró generar información para clarificar lo sucedido. Se reitera la importancia de siembra de áreas refugio no-Bt, el monitoreo aun en soja Bt y la adopción de los umbrales de daño (UD) establecidos para soja no-Bt en caso de constatar daño (aprox. 30 % de defoliación constantando la presencia de larvas vivas). |
Palabras claves : |
LAGARTA DE LA SOJA. |
Thesagro : |
LEPIDOPTERA; SOJA. |
Asunto categoría : |
H10 Plagas de las plantas |
URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/17042/1/Revista-INIA-72-marzo-2023-15.pdf
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Marc : |
LEADER 01290naa a2200277 a 4500 001 1064015 005 2023-04-12 008 2023 bl uuuu u00u1 u #d 022 $a1510-9011 100 1 $aCIBILS-STEWART, X. 245 $aCrónica del daño de la lagarta medidora (Rachiplusia nu) en soja Intacta®.$h[electronic resource] 260 $c2023 490 $a(Revista INIA; 72). 520 $aEn febrero de la pasada zafra se reportó, en nuestro país, la presencia y el daño de lagartas medidoras (Rachiplusia nu) en soja Bt (foto de portada y Figura 1). Se presentan aquí los resultados del trabajo que procuró generar información para clarificar lo sucedido. Se reitera la importancia de siembra de áreas refugio no-Bt, el monitoreo aun en soja Bt y la adopción de los umbrales de daño (UD) establecidos para soja no-Bt en caso de constatar daño (aprox. 30 % de defoliación constantando la presencia de larvas vivas). 650 $aLEPIDOPTERA 650 $aSOJA 653 $aLAGARTA DE LA SOJA 700 1 $aGONZALEZ, M. 700 1 $aPESSIO, M. 700 1 $aCALISTRO, P. 700 1 $aROSSI, C. 700 1 $aGIAMBIASI, M. 700 1 $aCHIARAVALLE, W. 700 1 $aABBATE, S. 700 1 $aBARAIBAR, N. 773 $tRevista INIA Uruguay, Marzo 2023, no.72, p.53-58.
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